MTOR hypermethylation may associate with the susceptibility and survival of SARS-CoV-2 infections to lung adenocarcinoma patients based on multi-omics data and machine learning

Recent studies have shown that lung adenocarcinoma (LUAD) patients have a higher risk and worse prognosis of COVID-19 caused by SARS-CoV-2 compared to normal samples. Whereas, in addition to the receptor for SARS-CoV-2, other genes also deserve attention. In our study, we identified 19 differentially methylated genes (DMGs) that were co-upregulated in LUAD and COVID-19 samples. These 19 DMGs mainly regulated the immune-related and multiple viral infection signaling pathways. Gene Ontology and pathway enrichment analysis were applied with these genes. Then, 6 key DMGs (MTOR, ACE, IGF1, PTPRC, C3, and PTGS2) were identified by constructing and analyzing the protein-protein interaction (PPI) network. Besides, MTOR was significantly associated with 5 prognostic markers (CDO1, NEURL4, SMAP1, NPEPPS, IQCK) identified by survival analysis based on machine learning. In total, MTOR hypermethylation may be related to the susceptibility of LUAD patients to SARS-CoV-2 and the prognosis of LUAD patients suffering from COVID-19.