Burn Management using Enzymatic Debridement with Bromelain enriched Enzyme Mixture (Nexobrid™) - Case Series

Burns are complex injuries with multiple possible etiologies that can cause major morbidity and are associated with a high mortality risk. Bromelain-based Enzymatic Debridement has become a reliable and useful alternative to surgical debridement, which has been found to be most effective in mid- to deep dermal burns and mixed depth patterns. Enzymatic Debridement in circumferential burns to the extremity was studied by Fischer et al. who showed its effectiveness and safety for the prevention of compartment syndrome, reducing the need of surgical escharotomy. Our study included 10 patients aged 19 to 58 years of age, treated between October 2019 and September 2022. Enzymatic debridement is a viable alternative to surgical debridement that proves to have the advantages of rapid selective debridement and safety. Enzymatic debridement showed to be effective in circular lesions of the limbs, with no signs of compartment syndrome after the procedure, spontaneous reepithelization obtained, and no skin graft donor sites created.