Biofabrication of Cell-laden Auxetic dECM Scaffold Regulated Chondrogenic Markers under Cyclic Tension Stimulation

This study aimed to investigate the effects of human chondrocytes-laden auxetic scaffold under the cyclic tension stimulation by carrying out the decellularized extracellular matrix of rabbit meniscus (dECM) and light-curable gelatin (FGelMA) as the material substrate. The prepared photocurable bioink provided cells proliferation and morphological alterations. There was a trend to elevate cell numbers significantly compared with static culturing, and a wider spread of cell expansion can also be found at the edge of the auxetic structure. Remarkably, the scaffold designed as an auxetic structure through digital light processing and combined with cyclic tension stimulation to further promote the synergetic effect on chondrogenic-related ECM markers of chondrocytes.