Highly Sensitive, Rapid, and Real-Time Detection of Hydrogen Sulfide in Human Blood Plasma Using MoSe2 Field-Effect Transistor

Rapid and real-time hydrogen sulfide (H2S) detection in human blood or plasma is required as it has physiological and pathophysiological relations with human health. An ultrasensitive field-effect transistor (FET) using a layered transition metal dichalcogenides is demonstrated to detect dissolved H2S in plasma. The biosensor effectively utilizes a few layers of MoSe2 as a channel material for the FET device. The fabricated biosensor exhibited the highest response of 78 at the lowest H2S concentration of 1
$\mu \text{M}$
and a wide linear dynamic range (between 1
$\mu \text{M}$
and 1 mM). With the lowest detection limit of 1
$\mu \text{M}$
, the fabricated biosensor is appropriate for quick and real-time detection of H2S in plasma for point-of-care applications. In the concentration range of 1–100
$\mu \text{M}$
, the FET device shows linear change in its drain current and the threshold voltage. However, the fabricated device is still a proof of concept and could open new technological avenues for directly detecting all the forms of free sulfide in plasma with rapid, real-time, and stable sensing performance for point-of-care applications.