Zr-Fc MOF Nanosheets Based Mass Spectrometry Platform for Metabolites Detection

Novel Zr-Fc metal-organic framework (MOF) nanosheets based laser desorption/ionization mass spectrometry (LDI MS) platform has been developed for metabolites detection. The ultrathin Zr-Fc MOF nanosheets was synthesized using the bottom-up method. Furthermore, by optimizing the conditions, Zr-Fc MOF nanosheets exhibited excellent performance as an LDI MS matrix without background interference. The Zr-Fc MOF nanosheets based LDI MS platform has been successfully applied to detect various amino acids with high signal intensity (~ 10
⁵
), which presents potential values in clinical metabolic analysis for disease diagnosis and evaluation.