Determining Zero Point of Blood Glucose Detection Through Potentiostat Circuit Configuration

Glucose meters have been developed for determining the hyperglycemic and hypoglycemic disorders as well as checking daily glucose levels for diabetic patients. Although multiple commercial glucometers have been presented, the attendance of interferences in the measuring of glucose is still a challenge. This problem can be managed using the proper design of potentiostat as the main part of glucometers. Here, we introduce a novel electrochemical circuit design comprising a microcontroller to specify the optimum zero point for the glucose measuring. The proper configuration of the potentiostat circuit leads to the correct detection of zero point for glucose. For this, the counter electrode (CE) is placed in high impedance mode, as well as the working electrode (WE) and reference electrode (RE) in the feedback path of the transimpedance amplifier circuit. The linear range of the proposed sensor was detected in the concentration ranges of 57–600 mg/dL with a linear equation of
${y}={0.0018} {x}-{0.0693}$
and a sensitivity of 0.0018. The final cost and characteristics of our proposed circuit were better than some other devices.