Millimeter Waves Alter the Genomic Architecture and Transcriptome of Primary Human Fibroblasts

The current understanding of the biological effects of millimeter waves (MMWs) remains incomplete, and the interaction mechanisms causing these effects are largely unknown. We found that exposure of primary human fibroblasts to MMWs results in modified DNA secondary structure formation, altering the transcriptome and enriching many biological pathways without inducing DNA damage. This establishes the potential for therapeutic application of MMWs to induce targeted modifications to genomic architecture for the purpose of controlling gene expression and specific pathways.