Spectral approaches for depth analysis in diffuse optical diagnostics modalities

Strong dispersion of biotissue optical properties in visible and NIR ranges determines difference in probing depths in optical diagnostics modalities thus allowing to control probing depth by the choice of the wavelength range. The paper discusses spectral dependence of the probing depth and the accuracy of oxygen saturation reconstruction in diffuse reflectance spectroscopy and reviews dual-wavelength approach in fluorescence imaging.