Alternating Learning Approach for Variational Networks and Undersampling Pattern in Parallel MRI Applications

This work proposes an alternating learning approach to learn the sampling pattern (SP) and the parameters of variational networks (VN) in accelerated parallel magnetic resonance imaging (MRI). We investigate four variations of the learning approach, that alternates between improving the SP, using bias-accelerated subset selection, and improving parameters of the VN, using ADAM. The variations include the use of monotone or non-monotone alternating steps and systematic reduction of learning rates. The algorithms learn an effective pair to be used in future scans, including an SP that captures fewer k-space samples in which the generated undersampling artifacts are removed by the VN reconstruction. The quality of the VNs and SPs obtained by the proposed approaches is compared against different methods, including other kinds of joint learning methods and state-of-art reconstructions, on two different datasets at various acceleration factors (AF). We observed improvements visually and in three different figures of merit commonly used in deep learning (RMSE, SSIM, and HFEN) on AFs from 2 to 20 with brain and knee joint datasets when compared to the other approaches. The improvements ranged from 1% to 62% over the next best approach tested with VNs. The proposed approach has shown stable performance, obtaining similar learned SPs under different initial training conditions. We observe that the improvement is not only due to the learned sampling density, it is also due to the learned position of samples in k-space. The proposed approach was able to learn effective pairs of SPs and reconstruction VNs, improving 3D Cartesian accelerated parallel MRI applications.