Computer modeling of cardiac repolarisation for the analysis of the electrocardiogram

This paper describes the methods and techniques that were used to develop a computer model of left ventricular repolarisation, and the results obtained using the model to investigate cardiac repolarisation and its manifestation on the surface electrocardiogram. We showed that normal T-waves can be generated by the model for a normal repolarisation of the left ventricle, with a physiological value of dispersion of repolarisation of 20 ms. The time course of body potentials agrees with published experimental results. Increasing dispersion to a pathological value of 100 ms, T-waves became symmetric. The model was able to simulate normal U-waves correctly.