Designing and Modeling a Centrifugal Micromixer for Continuous Circulating Tumor Cells Lysis

Nowadays lysis of Circulating Tumor Cells (CTCs) has a vital role in diagnosis and treatment of cancer diseases. Microfluidic techniques have great potential in this subject and Lab on CD (LOCD) devices are one of the branches of these techniques. In this study, a device on a disk is simulated using LOCD applications. CTC separated from whole blood, is then injected into the mixer for continuous chemical cell lysis. For this purpose, an omega shaped (
$\Omega$
) channel is considered for creating stronger dean flow and improving mixing quality. In order to survey the efficiency of this device, mixing quality is introduced in this study to access the efficiency of mixing. The effect of adding an extension to the cross section is investigated to show desirable mixing efficiency in only 100 [rpm]. Moreover, the positions of inlet flows are studied and the best result is presented. The presented study concludes the lysis buffer and particle flow mixes to 99.77% quality.