2-D Nanomaterials Assisted LSPR MPM Optical Fiber Sensor Probe for Cardiac Troponin I Detection

This study used localized surface plasmon resonance (LSPR) technology to develop an optical fiber biosensor for the detection of cardiac troponin I (cTnI). The etched core mismatch, multimode–photosensitive–multimode (MPM) fiber structure, is used in this study. Following that, graphene oxide (GO), gold nanoparticles (AuNPs), and molybdenum disulfide nanoparticles (MoS
₂
-NPs) are immobilized to the etched MPM surface to improve the sensitivity and stability of the sensor probe. Furthermore, the sensing surface is functionalized with an enzyme to improve the selectivity performance. The absorption spectrum of nanomaterials is determined using a UV-Vis spectrophotometer and a transmission electron microscope (TEM), while the surface of an immobilized probe was observed using a scanning electron microscope (SEM). To determine the sensor’s reliability, a variety of experiments are carried out, including sensing, reusability, reproducibility, stability, pH, and selectivity. Sensitivity of 3.4 pm/(ng/mL), a correlation coefficient of 0.928, limit of detection (LoD) of 96.2638 ng/mL, and linear range of 0–1000 ng/mL are among the sensor’s final performance specifications.