Sensitivity Analysis in Clinical Trial Simulation At Sas Institute

Clinical trial enrollment is expensive, important, and subject to many uncertainties. Simulation captures these uncertainties, so SAS® Institute created the Clinical Trial Enrollment Simulator (CTrES) as a tool specifically for enrollment planning. However, simulation provides no mathematical expression from which to extract sensitivity measures that are critical for problem diagnosis and management. This paper describes sensitivity analysis technology created for CTrES requiring only the output data obtained from simulation of the base scenario, and demonstrates it on a realistic enrollment planning problem for the United States.