Electrochemical Determination of Dopamine at Nafion and β-Cyclodextrin-Functionalized Multi-Walled Carbon Nanotubes Composite Modified Glassy Carbon Electrode

Dopamine (DA) has been found as a significant neurotransmitter. Since abnormal concentrations of DA can induce a series of serious diseases. Simple, economical and efficient sensors should be developed to detect DA. In this study, a highly selective electrochemical sensor was developed to detect DA using nafion (NA) and multi-walled carbon nanotubes-
$\beta $
-cyclodextrin (MWCNTs-
$\beta $
-CD) composite modified glassy carbon electrode (GCE). The MWCNTs-
$\beta $
-CD composite was prepared by mechanical grinding at ambient temperature, which could be an environment-friendly method. The as-prepared MWCNTs-
$\beta $
-CD composite was characterized with Scanning electron microscopy and Fourier-transform infrared spectra. Such NA/MWCNTs-
$\beta $
-CD/GCE based sensor had high performance with a detection ranges from 0.01 to
$1 ~\mu \text{M}$
and from 1 to
$10 ~\mu \text{M}$
as well as a detection limit of
$0.005 ~\mu \text{M}$
. Moreover, the sensor was found with high selectivity, stability, reproducibility and satisfying recovery rate to detect DA in samples. A novel DA sensor was developed with high sensitivity using NA/MWCNTs-
$\beta $
-CD/GCE, which could be promising to detect DA in pharmaceutical samples.