Preoperative Monitoring Using Implantable, Multimodal, Multichannel Probe

Epileptic brain activity can be monitored using multiple pathophysiological signals. Thus, a six-channel flexible multimodal multichannel probe that can simultaneously record electrocorticography, hemodynamics, and brain temperature (BrT) was proposed to improve the accuracy of epilepsy diagnosis. The probe has six channels. Elements were arranged such that all modalities measured the same cortical region. In this study, three seizures were detected in epilepsy patients with cortical dysplasia during preoperative monitoring by using the proposed probe. A change in the direct current potential and increase in BrT were observed in all seizures. Regarding hemodynamic changes, although there was a disturbance due to an unknown cause in one seizure, an increase in oxyhemoglobin (HbO
2
) and total hemoglobin (HbT), decrease in deoxyhemoglobin (Hbb) followed by a decrease in HbO
2
and HbT, and increase in Hbb were observed in all seizures. These seizure-related changes obtained through each modality were consistent with the results of previous studies.