Quantifying partition-based Kolmogorov-Sinai Entropy on Heart Rate Variability: a young vs. elderly study

In the last decades, a considerable effort has been devoted to quantify complexity in physiological time series, with a particular focus on heart rate variability (HRV). To this end, exemplary quantifiers including Approximate Entropy and Sample Entropy have successfully been applied by leveraging on statistical approximation and further parametrization through the definition of tolerance and embedding dimension, among others. In this study, we investigate the use of the Algorithmic Information Content, which is estimated through an effective compression algorithm, to quantify partition-based Kolmogorov-Sinai (K-S) entropy on HRV series. We test such a K-S estimate on real data gathered from the Fantasia database, aiming to discern young vs. elderly complex dynamics. Experimental results show that elderly people are associated with a lower HRV complexity and a more predictable behavior, with significantly lower partition-based K-S entropy than the young adults. We conclude that partition-based K-S entropy may effectively be used to investigate pathological conditions in the cardiovascular system, complementing state-of-the-art methods for complexity assessment.