Multi-Channel Biopotential Acquisition System Using Frequency-Division Multiplexing With Cable Motion Artifact Suppression

A multi-channel, CMOS-based biopotential acquisition system is presented that uses amplitude modulated, frequency division multiplexing (AM-FDM) to decrease wire count and provide resilience against motion artifacts and cable noise. Differential active electrode (AE) pairs capture surface biopotential signals, each modulated by a different carrier frequency and combined via current-domain summing. The presented approach requires only a single wire for signal transmission between AEs and back-end readout, along with clock and ground wires, to support multiple active electrodes using a 3-wire cable. Frequency modulation prior to transmission mitigates the effect of low-frequency cable motion artifacts and 50/60 Hz mains interference in the cable. A prototype FDM-based biopotential acquisition system was implemented in a 180 nm CMOS process, including a four-channel front-end active electrode IC for signal conditioning and modulation, and a back-end IC for demodulation and digitization. Each channel occupies 0.75 mm $^\text{2}$ and consumes 43.8 $\mu$ W, inclusive of ADC power. Using both AE and BE ICs, a four-channel biopotential recording system is demonstrated using a 3-wire interface, where the system achieves attenuation of low-frequency cable motion artifacts by 15X and 60 Hz mains noise coupled into the cable by 62X.