Resveratrol/Ro5-3335 Nanoemulsion for Potential Application in Retinal Drug Delivery

Proliferative Diabetic Retinopathy (PDR) can form fragile neovessels enhancing the risk of bleeding and increasing intraocular pressure. It is necessary to develop new treatments based on nanoemulsions administered ophthalmologically, that could reach specific sites desired and have minimally invasive drug release for the patient. In this study, Resveratrol/Ro5-3335 nanoemulsions (RSV-Ro5 NEs) stabilized with polyvinyl alcohol (PVA) were synthesized by the phase inversion method, both active principles have never been combined before in previous investigations. The physicochemical characterization of the nanoemulsion was examined for Droplet Size using Dynamic Light Scattering (DLS) and Nanoparticle Tracking Analysis (NTA), Droplet Morphology using Transmission Electron Microscopy (TEM), and Fourier Transform Infra-red spectroscopy analysis (FTIR).By controlling variables such as the molecular weight of the polymer, stirring, dripping, and temperature, stable-in-time spherical nanodroplets were obtained with an average of less than 500 nm. The above drugs can modulate retinal inflammation and inhibit or prevent the formation of abnormal blood vessels. The data reported in this work suggest the potential of these formulations in future treatments to control pathological ocular angiogenesis diseases.