Simulation of time-integrated dynamic speckle patterns in biomedical optics

The simulation of statistically accurate 2D time-integrated dynamic speckle patterns using a model that accounts for spatially varying sample properties (such as scatterer motion and decorrelation time) is yet to be presented in biomedical optics. We propose a solution to this important problem based on the Karhunen-Loève expansion of the field autocorrelation function, and apply our method to the formalisms of both laser speckle contrast imaging and diffuse correlation spectroscopy.