Graphene oxide-coated microfiber interferometric biosensor for detecting AFP

In this paper, a graphene oxide (GO) functionalized microfiber is proposed and used for immunodetection of alpha-fetoprotein. First, the standard single mode fiber was formed into tapered structure by optical fiber fusion splicer, then microfiber was fabricated by the heat-drawing. Finally, a functionalized microfiber coated with GO is used to detect AFP. The results demonstrated that the detection sensitivity of microfiber is ~1.471 nm/log(mg/ml) within the range of 1 to 10000 pg/mL. Due to high sensitivity, compact structure, low cost, the microfiber coated with GO has great potential in medical field.