An Efficient Prediction Method for Coronary Heart Disease Risk Based on Two Deep Neural Networks Trained on Well-Ordered Training Datasets

This study proposes an efficient prediction method for coronary heart disease risk based on two deep neural networks trained on well-ordered training datasets. Most real datasets include an irregular subset with higher variance than most data, and predictive models do not learn well from these datasets. While most existing prediction models learned from the whole or randomly sampled training datasets, our suggested method draws up training datasets by separating regular and highly biased subsets to build accurate prediction models. We use a two-step approach to prepare the training dataset: (1) divide the initial training dataset into two groups, commonly distributed and highly biased using Principal Component Analysis, (2) enrich the highly biased group by Variational Autoencoders. Then, two deep neural network classifiers learn from the isolated training groups separately. The well-organized training groups enable a chance to build more accurate prediction models. When predicting the risk of coronary heart disease from the given input, only one appropriate model is selected based on the reconstruction error on the Principal Component Analysis model. Dataset used in this study was collected from the Korean National Health and Nutritional Examination Survey. We have conducted two types of experiments on the dataset. The first one proved how Principal Component Analysis and Variational Autoencoder models of the proposed method improves the performance of a single deep neural network. The second experiment compared the proposed method with existing machine learning algorithms, including Naïve Bayes, Random Forest, K-Nearest Neighbor, Decision Tree, Support Vector Machine, and Adaptive Boosting. The experimental results show that the proposed method outperformed conventional machine learning algorithms by giving the accuracy of 0.892, specificity of 0.840, precision of 0.911, recall of 0.920, f-measure of 0.915, and AUC of 0.882.