Syzygium polyanthum Ethanol Extract Ameliorates Benzene-induced Nephrotoxicty in Rats

The kidneys are important organs that help maintain the composition of blood by preventing the build-up of waste products. The exposure to hydrocarbons plays an important role in the development of renal dysfunction especially benzene. Syzygium polyanthum is a secondary metabolites that contains antioxidants and it has the ability neutrelizing benzene toxicity. Therefore, this study aimed to evaluate the ability of ethanolic extract of Syzygium polyanthum (EESP) to prevent kidney damage after benzene exposure. This study was divided into 11 groups of normal, benzene 3, benzene 6, vitamin C 3, vitamin C 6, EESP 400 3, EESP 400 6, EESP 600 3, EESP 800 3 and EESP 800 6 and given for 21 days, on 22 day the rats were dissected. The obtained blood was centrifuged at 5000 RPM for 15 minutes. Furthermore, the supernatant was taken and the parameters of urea, creatinine, uric acid, and NGAL were analyzed, respectively. The results showed that the extract doses of 400, 600, and 800 mg/kgbw reduced the levels of urea, creatinine, uric acid, and NGAL which were significantly different from the group that was only given benzene 3 and 6 (p< 0.05). Therefore, it can be concluded that the EESP has nephroprotective activity.