Improved PET Image Reconstruction for reduced radiopharmaceutical dose

We present results from the application of the Reconstructed Image from Simulations Ensemble (RISE) method in Positron Emission Tomography (PET) using a hardware phantom for varying count statistics. We compare our results with the scanner's OSEM with PSF correction and utilize the Contrast-to-Noise ratio to provide a quantitive metric. RISE compares favorably with OSEM both visually and quantitively.