Autopilot, Smart IoT Devices for Accelerating the Development of Bio-electronic Medicine

Summary form only given, as follows. The complete presentation was not made available for publication as part of the conference proceedings. Bio-electronic medicine has become a promising alternative for treating neural diseases. However, the development of bio-electronic medicines research relies greatly on understanding how the brain functions and identifying the biomarkers for distinguishing between normal and pathological states. This kind of knowledge usually requires intensive research with animal disease models. To fulfill such research demand, so as to accelerate the development of bio-electronic medicine, a miniaturized microsystem suitable for recording and stimulating multiple brain regions of a freely-moving animal has been designed and tested. In addition, the microsystem allows the stimulation to be triggered only upon the detection of particular disease-related signatures. This function is especially crucial for investigating novel neuromodulation protocols that improve therapeutic efficacy and minimize side effects. All the technologies above have been realized as the NeuLive system and verified with Parkinsonian rat models. Moreover, similar design concept is adopted to realize the Elite system for more general biomedical research, including voltammetry, impedance measurement, etc. Both NeuLive and Elite systems will be introduced and demoed in this talk.