Research on a Cell Proliferation Model Based on A549 Cell Line With Magnetic Field Stimulation

Mutation of the K-Ras gene has been widely found in non-small cell lung cancer. Compared with other mutations of lung cancer, the drugs cannot effectively target mutant K-Ras. However, the mitosis of cancer cells is vulnerable to external interference. Our previous study showed that electromagnetic fields (MFs) could suppress cell proliferation. In this article, a cell proliferation model based on the A549 cell line was established while considering the effects of MFs. In addition, the parameters of the A549 cell proliferation model were regressed by the finite difference method and verified by numerical simulation. Based on the calculations, the density of the A549 cells reflects the trend of measured data from optical microscopy. This approach not only helps reveal the mechanism of MFs on cancer cells but also suggests a new way to predict the effects of magnetic stimulation on cancer inhibition.