Menstrual Regulation Delivered by Angelicae Sinensis Radix

Angelicae Sinensis Radix, also called Dang-Gui in Chinese, is an important and widely used natural product in traditional Chinese medicine (TCM) formulae with therapeutic properties of “menstrual regulation”. However, the underlying mechanisms on the molecular-interaction-level are still under exploration. In this study, based on evidenced bioactive compounds, targeted genes and proteins, different level functional annotations on gene ontology biological processes (GOBP) was deployed and then validated with microarray data. As a result, participating-fold analysis of targeted proteins revealed that the rhythmic process is the top GOBP. Further analysis indicated that the ovulation cycle process is associated with both the rhythmic process and TCM clinical relevance. After that, a kernel candidate regulation network was constructed towards the therapeutic properties of menstrual regulation identified in TCM that is delivered by Dang-Gui.