The evaluation of tumor vascularization as a prognostic factor of plasmonic phothothermal therapy efficiency

The tumor vascularization in rats with transplanted cholangiocarcinoma was assessed by US power Doppler before plasmonic photothermal therapy (PPT). For PPT, the multiple intravenous injections of PEG-coated gold nanorods and irradiation by 808-nm NIR diode laser were used. We have shown that gold nanoparticles accumulation in tumor and efficiency of PPT are associated with the degree of vascularization of a tumor.