Laser spectroscopic method for assessing the effectiveness of photodynamic therapy (controlled PDT)

This work presents the developed method and equipment for assessing the effectiveness of treatment using photodynamic therapy (PDT). As a photosensitizer (PS), the drugs "Photoditazin" and "Alasens" were used. The problem of spectral separation of laser radiation and fluorescence of 5-ALA-induced protoporphyrin IX or Chlorin e6 was solved by selecting a combination of optical filters. The time of laser irradiation varied from 6 to 20 min, depending on the fluorescence index of the irradiated area, the energy dose was 100-200 J/cm
²
. The results showed the effectiveness of the new approach and equipment for conducting controlled PDT.