Fouling-proof real-time optosensors for polyvalency-based characterization of circulating antibodies

Biosensors and an original assay format are developed to completely characterize antibodies in human serum and resolve the bottleneck of label-free measurements of kinetics, which is non-specific binding of serum components. The achieved analytical characteristics which surpass those of the majority of label-based biosensors are further improved by magnetic nanoparticles.