Modeling and Design Considerations for Resistive Impedance-Based Flow Cytometry

Recent developments in impedance-based flow cytometry have shown it to be a promising alternative to conventional optical approaches for point-of-care (POC) applications. While analysis tools such as finite element analysis provide unique insight for designers of such systems, they provide limited utility for system-level design and are computationally prohibitive for large design space explorations. In this work, an electrical model is presented for resistive impedance-based cytometry to inform system-level design choices such as bandwidth requirements and to provide a flexible way of simulating particle transits for arbitrary arrangements of particles and electrodes. The model is validated using measured results from a microfluidic flow cell.