Design and Development of a Mechatronic System for Releasing and Recycling of Nanomagnetic-insulin

A fully implantable artificial pancreas system with intraperitoneal glucose sensing and insulin releasing has the advantage of a fast insulin response and no psychological burden to diabetic patients. However, it may require frequent surgical interventions to refill insulin after insulin is used out. By studying the metabolic pathway of insulin, in this paper we propose a mechatronic system for releasing and recycling of nanomagnetic -insulin to demonstrate the feasibility of achieving magnetic-assisted insulin recycle and reuse, which may reduce the needs of insulin refill and mitigate hypoglycemia. In the prototype developed in this study, the mechanical structure, driving principle, control circuit and related programming of the mechatronic system are introduced. Finally, the basic functions of the mechatronic prototype are verified by ex vivo experiments.