Mutational profile of Diffuse Large B-cell Lymphoma with central nervous system relapse: analysis of CBioPortal for Cancer Genomics database

In this study, based on the information presented in the specialized resource CBioPortal for Cancer Genomics database, the data on the diffuse large B-cell lymphoma (DLBCL) mutation profile detected by next generation sequencing (NGS) methods have been analyzed. The features associated with a high risk of secondary central nervous system (CNS) involvement have been highlighted. In patients with DLBCL and secondary CNS involvement, the most frequently mutated genes were MYD88, PIM1, CARD11 and CD79B. These genes related to the BCR/NF-kB signaling pathway. The MYD88, PIM1 and CD79B genes mutations were often combined and, in total, occurred in 39.6% of cases in patients with CNS relapsed DLBCL.