Influence of Immobilized Subtilisins on Perfomance Indicators of Rat Heart in Experiment

The immobilized subtilisins are bacterial proteinases with a high thrombolytic activity, capable of improving peripheral blood circulation by dissolving the blood clot and reducing manifestations of endothelial dysfunction. This article presents the materials of the effect of immobilized subtilisins on performance heart indicators in the experiment. The action of these proteinases was studied on a model of isolated rat heart according to Langendorff. Indicators of heart rate (HR), pressure developed by the left ventricle (LVP), heart efficiency (HE) were selected for registration. It was shown when adding the immobilized subtilisins, an increase of the left ventricular contraction force and a decrease in a heart rate were observed. The results indicate that immobilized subtilisins have positive inotropic and negative chronotropic effects.