Effectiveness Test of Wound Healing based Virgin Coconut Oil toward Commercial Products on Rabbits

The skin is permanently exposed to the external environment and is very vulnerable to the appearance of various types of lesions such as burns, boils, and other injuries. Wound healing is a complex biological event and is influenced by extrinsic and intrinsic factors which can cause complications. Virgin Coconut Oil (VCO) is rich in the role of vitamin E in the mechanism of cell retention in cell organs, significantly increasing the activity of antioxidant enzymes, fibroblast proliferation, and neovascularization. This study aims to determine the effectiveness of the VCO in experimental cuts. Subjects (rabbits suffering from cut wounds by treating VCO commercial products topically) were divided into four groups (i.e., negative control, positive control treatment with betadine, treatment with artificial VCO, treatment with commercial VCO. Then the wound diameter was measured on days 0, 3, 7, 15 and21. On the last day, treated rabbits were anesthetized, and wound tissue was taken for histological examination. The results showed that the VCO treatment had potentially developed into wound care products. The VCO administration group affected the epithelial cell thickness by about 641.5 μm lower than other groups, and also have an average number of epithelial cells more than other groups.