Computer-assisted Inductive Moderate Hyperthermia Planning For Breast Cancer Patients

This paper demonstrates the basic principles of personalized computer-assisted regional inductive moderate hyperthermia (RIMH) planning for locally advanced breast cancer and treatment outcomes of stage IIB-IIIA patients. COMSOL Multiphysics 5.4 was used to modulate the distribution of the electromagnetic and temperature fields in the tumor during RIMH based on magnetic resonance imaging scans. Patients were divided into 2 groups. The control group received 4 courses of FAC (5-fluorouracil, doxorubicin, cyclophosphamide) neoadjuvant chemotherapy, while the main group received a 30-minute RIMH session at a frequency of 27.12 MHz and an output power of 50 W delivered by MagTherm (Radmir, Kharkiv, Ukraine) after each neoadjuvant chemotherapy administration. RIMH in combination with neoadjuvant chemotherapy significantly improved tumor response by 15.9% (p = 0.034) and the 5-year overall survival by 14.6% (p = 0.024).