Mathematical Modeling of Morphometric Parameters of Thyroid Gland Structure

A comprehensive analysis of thyroid morphological parameters in various forms of thyroid pathology by mathematical modeling methods is performed. Histological methods have been used to study the thyroid gland samples in 199 patients of both sexes aged 21 to 74 years who underwent surgical treatment. The experimental data were studied by factor and discriminant analysis methods. Investigating 60 experimental parameters by the factor analysis, 14 main factors were identified, indicating 14 likely trends in the dynamics of the thyroid gland structure due to an increase in the severity of pathological processes. The discriminant analysis showed that when examining only quantitative indicators of the thyroid gland structure, cases of erroneous variant attribution in theoretical groups are possible, however, when examining the totality of indicators, a 100% correct distribution of cases by pathology groups was observed. As a result of the factor analysis, the initial system of 60 morphological indicators of the thyroid gland with various forms of pathology was minimized to 14 new non-correlating parameters (main factors), reflecting the main patterns in morphology changes in organ pathology. As a result of the discriminant analysis of the thyroid morphological parameters with various types of pathology, the importance of semi-quantitative parameters of the thyroid structure is revealed.