A Novel Technology of Multi-pinhole SPECT for Human Myocardial Perfusion Imaging

A novel technology of multi-pinhole (MPH) SPECT for human myocardial perfusion imaging (MPI) by increasing angular sampling. In this study, the efficiency of MPH SPECT is 0.06%, four-fold higher than Dual-detector LEHR SPECT (typically 0.015%), we acquired projection data of patient MPI for rest and exercise with 12-pinhole collimator and Siemens Symbia T16. There are two cases for MPH SPECT scan in V mode: one view from -170°of main turning device, two views from -170°and -135°. Acquisition time of MPH SPECT was 5 minutes for single and dual angles, and the acquisition of Siemens was 15 minutes. MPH calibration is essential to generate system transfer matrix, which will be employed to iterative reconstruction. Projection data were reconstructed with a Pixel-based Ordered Subset-expectation Maximization (POSEM) reconstruction algorithm. Reconstructed results showed that dual-angle imaging results have better uniformity than single-angle imaging, and MPH SPECT has higher spatial resolution than Siemens Symbia T16 with reduced acquisition time. The short acquisition time of MPH can increase SPECT throughput and reduces the possibility of artifacts due to patient movement. More clinical trial for MPH dual angular sampling performance evaluation will be carried out.