Cumulative effect of electroporation pulses and drug transport in cancerous tissue

Cancer has reached worrying levels of proliferation. Research and the study of therapies that contribute to their treatment are increasingly necessary. It has been observed that using electroporation maximizes the entry of drugs into the cells, enhancing their effects, which is known as electrochemotherapy. In this work, experimental data describing the effect of pores accumulation in the cell membrane during the application of electrical pulses in a macroscopic mathematical model of drug transport using nonlinear regressions and the least squares method are implemented. The results show that the use of experimental data with mathematical models, allows to improve the predictions of drug entry, obtaining results closer to reality that can be used for the planning of treatments with electrochemotherapy.