Skin-Attachable and Implantable Polymer Microneedle Biosensor for Continuous Glucose Monitoring

In this paper, we have newly designed and fabricated horseshoe-shaped skin attachable minimally invasive wearable patch with implantable microneedle biosensor for continuous glucose monitoring in interstitial fluid (ISF). In order to reduce the effects of skin movement or external stress on the fabricated sensor, we considered both hardness and stretchability of the microneedle and appropriate material. The fabricated microneedle biosensor exhibited an excellent amperometric response to glucose molecules as much as 128.65 μA/mM·cm
²
and ultra-low limit of detection (LOD) as 0.198 μM. Furthermore, the linear range of the sensor was indicated up to 30 mM in two glucose concentration regions.