Double Synchronization Based on DNA Strand Displacement Reaction

As an important part of biological computing, DNA strand displacement technology is used to construct complex biochemical circuits. Reversible molecular chemical reactions are basic chemical reactions. In this study, based on DNA strand displacement and reversible molecular chemical reactions, catalysis, degradation, annihilation and synchronization reaction modules were proposed. These chemical reaction modules were extended to the molecular level by DNA strand displacement. The function of these modules was confirmed, and the relationship between reaction rate and reaction concentration was also analyzed. Applying these modules to the six-input buffered oscillator, the input-output synchronization of the oscillator can be realized.