Fuzzy Predictions Regarding In Vitro Behavior of Cells Line Under Cytostatic Treatment

Behavior evaluation of tumor and normal cell lines, under the influence of mixture between cytostatic and immunomodulatory compounds represents a challenge in oncologic research, because it is expected that in the presence of immunomodulatory compound, the normal cells will be less affected and the tumor cells will be destroyed much more. The aim of this paper is to predict the behavior of tumor cell line (FaDu) and normal cell line (HUVEC) under the influence of cytostatic compound named Cisplatin (CisPt) and under the influence of immunomodulatory compound named Curcumin (CR), in order to obtain an optimal mixing ratio between these two compounds. Based on the results obtained in Lab regarding the response of the two cell lines evolution vs. the treatment with each reagent in the concentration range of (0-100μM/mL), it was tried to model the behavior of the system in presence of these two compounds, using a fuzzy prediction. The obtained results were compared with predictions resulted from fuzzy simulation. Analyzing the numeric values, the best results were obtained in the case of prediction regarding HUVEC behavior with a fuzzy simulation.