Multiparametric Ultrasound for the Targeting of Prostate Cancer using ARFI, SWEI, B-mode, and QUS

Prostate cancer diagnosis using standard transrectal ultrasound (TRUS) and systematic biopsy is challenging. To improve the performance of TRUS imaging, we combined it with acoustic radiation force impulse (ARFI) imaging and shear wave elasticity imaging (SWEI) to enhance lesion contrast into a multiparametric ultrasound (mpUS) synthesized image using a linear support vector machine (SVM). The SVM was trained on one subset of patients (N=15) and applied to a second subset (N=15) imaged with a different transducer. mpUS imaging identified 79% of clinically significant PCa in the second cohort with a PPV of 95%.