Miniaturized Drug Delivery System for Biomedical Applications

A miniaturized 3D printed drug delivery device powered wirelessly is presented. The device is composed of an electrochemical micropump, a 3D printed reservoir with microneedles, and a wireless powering unit. The electrochemical pump features an expandable (up to 300%) Parylene C micro-bellows membrane fabricated by mold casting, using a two-photon polymerization 3D printing technique. The hollow microneedles are 100 μm in diameter and 300 μm long. The fabrication process offers customizable device properties, where the shape, size, and performance can be tailored to fit a wide range of in vivo drug delivery applications. Delivery of 3.8 ± 0.3 μL within 10 seconds of actuation is demonstrated, using inductive wireless powering at a distance of 10 mm between the primary and secondary coils.