Preparation of Serum Albumin Loaded Injectable Silica-Gel Matrix

Biomolecules play an active role in tissue regeneration. It is suggested that these biomolecules can be more efficient once the delivery is provided locally in the meant of with the local drug delivery systems. In the literature, the use of silicon dioxide gel matrix as a drug delivery system for different therapeutic agents are presented. The aim of this study is to prepare a silica gel drug delivery system that can be used as a bioactive molecule delivery system and to investigate the release profile of biomolecules by considering the biocompatibility of silica gel matrices and their positive effects on tissue regeneration. The methods intended to be followed to accomplish the stated objectives are to produce biocompatible silicon dioxide gel matrix by sol-gel method and to characterize the resulting silica gel matrices by testing both chemical content and physical properties and injectability. The release profile of BSA (Bovine Serum Albumin) protein from silica matrices as biomolecules is determined from optimized silica gel matrices. In this study, it was found that silica gel matrices are capable of delivering effective biomolecules and providing a sustained drug release profile.