Developing Silicate Additive Antibacterial and Osteoinductive Injectable Bone Grafts

In recent years, a striking increase in the number of commercial products has emerged with the introduction of first injectable bone grafts. Bone substitutes developed as highly water retained hydrogel structures and calcium phosphate-based ceramic composites have gained popularity especially in orthopedics and maxillofacial applications. The fundamental requirement of these injectable bone grafts are having radiopaque characteristic that allows surgeons to detect graft material after the surgery, antibacterial efficacy to prevent infections and gaining partial osteoinductive characteristic to support bone tissue regeneration. Therefore, the aim of this study was to develop silicate additive biocompatible, radioopaque and partial osteoinductive synthetic injectable bone grafts that do not need mixing during surgical application.