Production and Characterization of Ibuprofen Particle Layer Generated by Pulsed Laser Deposition (PLD)

Pulsed Laser Ablation (PLA) has been demonstrated to be suitable for the generation of thin layers consisting of micrometer- and submicrometer-sized particles from a wide range of materials [1]. In case of drug particles with defined molecular and crystal structure, it is critical to preserve their characteristic structure during micronization in order to keep their pharmacological effects. Therefore PLA could be a non-conventional approach in drug formulation, as a simple and rapid grinding method. The medical applicability of the drugs produced by PLA strongly depends on their size. For example the best uptake of the poorly water-soluble oral and parenteral drugs can be achieved in the form of micro - or nanoparticles. With increased specific surface area the dissolution rate and/or the permeability could be improved, which could be useful by the traditional per os dosage forms. In the case of alternative administration such as intranasal and pulmonary application, decreased size is a determined factor also [2].