A Silk-Enabled Conformal Brain Electrode for Recording and Disease Treatment

We report an implantable conformal brain electrode directly on silk substrate and exploit their biomedical capabilities for neural recording and disease treatment in-vivo. A multi-layers electrode, fabricated with MEMS technology, is assembled with silk films, a dissolvable pure silk film as attaching insurance and insoluble silk film loaded with drug as function of disease treatment. This device enable real-time dynamic observation of electrocorticogram (ECoG) symptoms and spatiotemporal bioelectrical vibration across two hemispheres during epilepsy in-vivo in rat brain. The ECoG neural recording and epilepsy treatment in situ prove the great potential in multifunctional brain-machine-interface (BMI) technology for diagnosis and treatment.