Nautilus: A Precision-Guided Open Data Architecture for Big Omics Data Analysis

To make valuable omics data useful is becoming more urgent in medical research. The need to provide information on what and how data can be useful for a particular research question has presented significant challenges in big data management and analysis. This paper describes a new open data architecture and its architectural components. It also introduces the Nautilus platform following the architecture design. We evaluate the performance of data management with the Nautilus platform and demonstrate that applying smart technologies improves the performance to cost tradeoff achieved in an experimental environment.