Integrated pH-Sensor for Medical Application in 180nm CMOS Technology

pH measurement has been reported as a key parameter for many applications such as biotechnology processes and clinical analysis, which this paper presents an integrated pH-sensor based on an ion-sensitive field-effect transistor ISFET to measure the blood pH, and detects if there is infection, for a value of pH different from 7.3 which conform a change in the blood acidosis. In this circuit design, we used an amplification block to increase the signal in order to release medical particles as well to send a notification to the medical team. The pH-sensor is design in TSMC 180nm CMOS technology.