Identifying Potential Hubs for Kidney Renal Clear Cell Carcinoma from TF-miRNA-Gene Regulatory Networks

Kidney Renal Clear Cell Carcinoma (KIRC) is the common kidney cancer and ranks 8^th among all other popular cancer types. Mostly adult humans are affected by this malignant disease. However, enough information have not been gathered for this special case of renal carcinoma. The experimentally validated data are also in a non uniformed form which makes it more difficult to decode the relation among miRNAs, genes and TFs. To address this obstacle in this current study, miRNAs, genes and TFs those associated with KIRC and played a significant role are considered as individual elements and a framework is proposed in order to find the connection among each entity. From this proposed framework some genes are identified those are not only targeted by miRNAs or TFs separately but also gene regulation has an impact due to the passive effect of TFs. From this network it is clear that gene regulation due to hsa-miR-146a-5p is indirectly controlled by those TFs also. For the further validation of these informative miRNAs and genes KEGG pathway and GO enrichment analysis are performed. In future study, these framework should be granted more attention in order to understand better prognosis about malignant diseases.